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AttributesValues
rdf:type
rdfs:label
  • [18F]L-FAC
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • [18F]L-FAC
NCI_META_CUI
  • CL423825
PDQ_Open_Trial_Search_ID
  • 683739
PDQ_Closed_Trial_Search_ID
  • 683739
FULL_SYN
  • 18F-FACABNCI
  • 1-(2-Deoxy-2-[18F]fluoroarabinofuranosyl) CytosineSNNCI
  • [18F]L-FACPTNCI
DEFINITION
  • A deoxycytidine analog and high-affinity substrate for deoxycytidine kinase (DCK), labeled with fluorine F 18, with potential diagnostic activity upon positron emission tomography (PET) imaging. [18F]L-FAC is preferentially taken up by and accumulated in cells with high deoxycytidine kinase (DCK) levels, such as in tumor cells with dysregulated nucleoside metabolism. Upon uptake through the nucleoside transporter, [18F]L-FAC is phosphorylated by DCK and, subsequently, the 18F moiety can be visualized upon PET imaging. As many nucleoside analog prodrugs are chemotherapeutic agents that require DCK for activation, [18F]L-FAC can potentially be used as a marker to predict chemotherapeutic efficacy of these prodrugs. In addition, as DCK is upregulated in certain immune cells, such as activated T-cells, [18F]L-FAC can also be used to measure immune activation in response to immunomodulating agents. DCK, a rate-limiting enzyme in the nucleoside salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes.NCI
code
  • C92576
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