About: NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes

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Attributes	Values
rdf:type	Class
rdfs:label	NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes
rdfs:subClassOf	Immunomodulating Agent
Semantic_Type	Pharmacologic Substance
Preferred_Name	NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes
UMLS_CUI	C2984526
PDQ_Open_Trial_Search_ID	681902
PDQ_Closed_Trial_Search_ID	681902
FULL_SYN	NSCLC Antigen-Loaded Dendritic Cell-derived ExosomesPTNCI
DEFINITION	Exosomes loaded with non-small cell lung cancer (NSCLC)-specific antigens, with potential immunostimulating and antineoplastic activities. Exosomes derived from autologous maturing dendritic cells (DCs) are pulsed with HLA-DP04-restricted MAGE-3, and HLA-A02-restricted peptides NY-ESO-1, MAGE-1, MAGE-3, and MART-1. Upon vaccination, these exosomes may stimulate natural killer (NK) cell activation and proliferation, restoration of NKG2D expression on NK cells, and antigen-specific T-cell responses. This may eventually lead to inhibition of tumor cell proliferation in NSCLC expressing these specific tumor antigens. These exosomes, nanovesicles secreted from DCs, are embedded with molecules necessary for potent immune responses on the exosomal surface, such as MHC class II molecules, CD40, ICAM-1, IL-15Ralpha, and NKG2D ligands.NCI
code	C91738

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