About: Dual PI3 Kinase/mTOR Inhibitor PKI-587     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Dual PI3 Kinase/mTOR Inhibitor PKI-587
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dual PI3 Kinase/mTOR Inhibitor PKI-587
NCI_META_CUI
  • CL412407
PDQ_Open_Trial_Search_ID
  • 651189
PDQ_Closed_Trial_Search_ID
  • 651189
FULL_SYN
  • Dual PI3 Kinase/mTOR Inhibitor PKI-587PTNCI
  • 1-(4-[[4-(dimethylamino)piperidin-1-yl]carbonyl]phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]ureaSNNCI
  • PKI-587CNNCI
  • PF-05212384CNNCI
DEFINITION
  • An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, PI3K/mTOR kinase inhibitor PKI-587 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.NCI
code
  • C91732
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