About: Dual PI3 Kinase/mTOR Inhibitor GDC-0980     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Dual PI3 Kinase/mTOR Inhibitor GDC-0980
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dual PI3 Kinase/mTOR Inhibitor GDC-0980
NCI_META_CUI
  • CL412290
PDQ_Open_Trial_Search_ID
  • 639518
PDQ_Closed_Trial_Search_ID
  • 639518
FULL_SYN
  • Dual PI3 Kinase/mTOR Inhibitor GDC-0980PTNCI
  • GDC-0980CNNCI
DEFINITION
  • An orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor GDC-0980 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion.NCI
code
  • C91731
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