About: MDM2 Antagonist RO5045337     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MDM2 Antagonist RO5045337
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • MDM2 Antagonist RO5045337
NCI_META_CUI
  • CL421615
PDQ_Open_Trial_Search_ID
  • 581121
PDQ_Closed_Trial_Search_ID
  • 581121
FULL_SYN
  • MDM2 Antagonist RO5045337PTNCI
  • R7112CNNCI
  • RO5045337CNNCI
DEFINITION
  • An MDM2 (human homolog of double minutes-2; HDM2) antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.NCI
code
  • C91724
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