About: Urokinase-Derived Peptide A6     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Urokinase-Derived Peptide A6
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Urokinase-Derived Peptide A6
NCI_META_CUI
  • CL433998
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. A6 is a small piece of a protein called urokinase (an enzyme that dissolves blood clots or prevents them from forming). It is a type of antiangiogenesis agent and a type of antimetastatic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 377541
PDQ_Closed_Trial_Search_ID
  • 377541
FULL_SYN
  • uPA-derived Peptide A6SYNCI
  • urokinase plasminogen activator (uPA)-derived peptide A6PTNCI-GLOSSCDR0000658764
  • A6CNNCI
  • Urokinase-Derived Peptide A6PTNCI
  • A6PTNCI-GLOSSCDR0000658765
DEFINITION
  • An octapeptide (amino acids 136-143) derived from the proteolytic enzyme urokinase plasminogen activator (uPA), with potential antineoplastic activity. A6 is derived from the nonreceptor-binding domain and connecting region of urokinase. Administration of A6 inhibits the interaction of uPA with its receptor uPAR, and may inhibit endothelial cell motility and tumor cell invasion. uPA and uPAR promote extracellular matrix degradation and growth factor activation and correlate positively with angiogenesis, cancer cell invasion and metastasis.NCI
code
  • C91709
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