About: Galactomannan Derivative     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Galactomannan Derivative
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Galactomannan Derivative
UMLS_CUI
  • C1328725
PDQ_Open_Trial_Search_ID
  • 355829
PDQ_Closed_Trial_Search_ID
  • 355829
FULL_SYN
  • Galactomannan DerivativePTNCI
  • DavanatSYNCI
DEFINITION
  • A carbohydrate polymer composed of mannose and galactose, with chemotherapeutic enhancing activity. Galactomannan derivative binds to galectins on cell surfaces and may promote the transport of certain chemotherapeutics, such as 5-fluorouracil (5-FU), into tumor cells. This may increase the antineoplastic effect of 5-FU when administered concomitantly. Galectins are carbohydrate-binding proteins, upregulated on the surface of certain types of tumor cells, and may mediate cell association, survival and metastasis.NCI
code
  • C91703
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