About: Type I Diabetes Mellitus Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Type I Diabetes Mellitus Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Type I Diabetes Mellitus Pathway
UMLS_CUI
  • C2984334
KEGG_ID
  • hsa04940
ALT_DEFINITION
  • Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).KEGG
FULL_SYN
  • Type I diabetes mellitusPTKEGG
  • Type I Diabetes Mellitus PathwayPTNCI
code
  • C91529
is someValuesFrom of
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