About: RIG-I-Like Receptor Signaling Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • RIG-I-Like Receptor Signaling Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • RIG-I-Like Receptor Signaling Pathway
UMLS_CUI
  • C2984316
KEGG_ID
  • hsa04622
ALT_DEFINITION
  • Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.KEGG
FULL_SYN
  • RIG-I-Like Receptor Signaling PathwayPTNCI
  • RIG-I-like receptor signaling pathwayPTKEGG
code
  • C91507
is someValuesFrom of
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