About: Small Cell Lung Cancer Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Small Cell Lung Cancer Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Small Cell Lung Cancer Pathway
rdfs:subClassOf	Cancer Pathway
Semantic_Type	Functional Concept
Preferred_Name	Small Cell Lung Cancer Pathway
UMLS_CUI	C2984312
KEGG_ID	hsa05222
ALT_DEFINITION	Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 20% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumor suppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.KEGG
FULL_SYN	Small cell lung cancerPTKEGG SCLC PathwaySYNCI Small Cell Lung Cancer PathwayPTNCI
code	C91502
is someValuesFrom of	nodeID://b642385 nodeID://b642442 nodeID://b642483 nodeID://b642826 nodeID://b646385 nodeID://b646494 nodeID://b652607 nodeID://b653972 nodeID://b654394 nodeID://b658018 nodeID://b662090 nodeID://b662183 nodeID://b668086 nodeID://b668103 nodeID://b668118 nodeID://b668143 nodeID://b674264 nodeID://b681320 nodeID://b682061 nodeID://b682688 nodeID://b683007 nodeID://b691363 nodeID://b691416 nodeID://b695068 nodeID://b695273 nodeID://b695592 nodeID://b696837 nodeID://b701193 nodeID://b705091 nodeID://b705133 nodeID://b706077 nodeID://b706480 nodeID://b706631 nodeID://b706732 nodeID://b706825 nodeID://b707368 nodeID://b707378 nodeID://b707388 nodeID://b708996 nodeID://b709040 nodeID://b709052 nodeID://b709064 nodeID://b718110 nodeID://b718123 nodeID://b718445 nodeID://b718469 nodeID://b720322 nodeID://b720339 nodeID://b725688

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 89 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software