About: Fc Gamma Receptor-Mediated Phagocytosis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Fc Gamma Receptor-Mediated Phagocytosis Pathway
rdfs:subClassOf	Immune Response Regulation Pathway Transport Pathway
Semantic_Type	Functional Concept
Preferred_Name	Fc Gamma Receptor-Mediated Phagocytosis Pathway
UMLS_CUI	C2984309
KEGG_ID	hsa04666
ALT_DEFINITION	Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsinization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.KEGG
FULL_SYN	Fc gamma R-mediated phagocytosisPTKEGG Fc Gamma Receptor-Mediated Phagocytosis PathwayPTNCI
code	C91499
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