About: Leishmaniasis Infection Pathway

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About: Leishmaniasis Infection Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Leishmaniasis Infection Pathway
rdfs:subClassOf	Infectious Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Leishmaniasis Infection Pathway
UMLS_CUI	C2984302
KEGG_ID	hsa05140
ALT_DEFINITION	Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses.KEGG
FULL_SYN	LeishmaniasisPTKEGG Leishmaniasis Infection PathwayPTNCI
code	C91491
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