About: Type II Diabetes Mellitus Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Type II Diabetes Mellitus Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Type II Diabetes Mellitus Pathway
UMLS_CUI
  • C2984301
KEGG_ID
  • hsa04930
ALT_DEFINITION
  • Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.KEGG
FULL_SYN
  • Type II Diabetes Mellitus PathwayPTNCI
  • Type II diabetes mellitusPTKEGG
code
  • C91490
is someValuesFrom of
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