About: Graft-Versus-Host Disease Pathway

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About: Graft-Versus-Host Disease Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Graft-Versus-Host Disease Pathway
rdfs:subClassOf	Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Graft-Versus-Host Disease Pathway
UMLS_CUI	C2984293
KEGG_ID	hsa05332
ALT_DEFINITION	Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines [tumour necrosis factor (TNF-alpha) and interleukin (IL-1)] secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells.KEGG
FULL_SYN	Graft-Versus-Host Disease PathwayPTNCI GVHD PathwayABNCI Graft-versus-host diseasePTKEGG
code	C91481
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