About: Glioblastoma Multiforme Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Glioblastoma Multiforme Pathway
rdfs:subClassOf	Cancer Pathway
Semantic_Type	Functional Concept
Preferred_Name	Glioblastoma Multiforme Pathway
UMLS_CUI	C2984291
KEGG_ID	hsa05214
ALT_DEFINITION	Glioblastoma multiforme (GBM) formation is either de novo (primary GBMs) or due to the progression of a lower grade glioma to a higher grade one through the acquisition of additional mutations (secondary GBMs). In primary GBM, disruption of the p53 pathway often occurs through loss of ARF, or less frequently through amplification of MDM2. Disruption of the RB pathway occurs through loss of INK4A. Amplification and/or mutation of the epidermal growth factor receptor (EGFR) is the most frequently detected genetic defect that is associated with primary GBM. In secondary GBM, loss of p53 and activation of the growth-factor-receptor-tyrosine-kinase signaling pathway (such as through overexpression of PDGF/PDGFR ) initiates tumour formation, whereas disruption of the retinoblastoma (RB) pathway contributes to the progression of tumour development. Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM.KEGG
FULL_SYN	GBM PathwayABNCI Glioma PathwaySYNCI GliomaPTKEGG Glioblastoma Multiforme PathwayPTNCI
code	C91479
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