About: Endocytosis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Endocytosis Pathway
rdfs:subClassOf	Metabolic Pathway
Semantic_Type	Functional Concept
Preferred_Name	Endocytosis Pathway
UMLS_CUI	C2984285
KEGG_ID	hsa04144
ALT_DEFINITION	Endocytosis is a mechanism for cells to remove ligands, nutrients, plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.KEGG
FULL_SYN	EndocytosisPTKEGG Endocytosis PathwayPTNCI
code	C91473
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