About: Dilated Cardiomyopathy Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Dilated Cardiomyopathy Pathway
rdfs:subClassOf	Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Dilated Cardiomyopathy Pathway
UMLS_CUI	C2984282
KEGG_ID	hsa05414
ALT_DEFINITION	Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. Genetically inherited forms of DCM ("familial" DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM. The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an "idiopathic" DCM. Current hypotheses regarding causes of "idiopathic" DCM focus on chronic viral myocarditis and/or on autoimmune abnormalities. Viral myocarditis may progress to an autoimmune phase and then to progressive cardiac dilatation. Antibodies to the beta1-adrenergic receptor (beta1AR), which are detected in a substantial number of patients with "idiopathic" DCM, may increase the concentration of intracellular cAMP and intracellular Ca2+, a condition often leading to a transient hyper-performance of the heart followed by depressed heart function and heart failure.KEGG
FULL_SYN	DCM PathwayABNCI Dilated cardiomyopathyPTKEGG Dilated Cardiomyopathy PathwayPTNCI
code	C91470
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