About: Melanogenesis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Melanogenesis Pathway
rdfs:subClassOf	Metabolic Pathway
Semantic_Type	Functional Concept
Preferred_Name	Melanogenesis Pathway
UMLS_CUI	C2984280
KEGG_ID	hsa04916
ALT_DEFINITION	Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.KEGG
FULL_SYN	MelanogenesisPTKEGG Melanogenesis PathwayPTNCI
code	C91468
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