About: Long-Term Depression Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Long-Term Depression Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Long-Term Depression Pathway
rdfs:subClassOf	Homeostasis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Long-Term Depression Pathway
UMLS_CUI	C2984275
KEGG_ID	hsa04730
ALT_DEFINITION	Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.KEGG
FULL_SYN	Long-Term Depression PathwayPTNCI Long-term depressionPTKEGG
code	C91463
is someValuesFrom of	nodeID://b641483 nodeID://b643014 nodeID://b647985 nodeID://b649115 nodeID://b664795 nodeID://b664818 nodeID://b664849 nodeID://b681201 nodeID://b682766 nodeID://b686269 nodeID://b688333 nodeID://b688595 nodeID://b688680 nodeID://b689087 nodeID://b689189 nodeID://b693277 nodeID://b695570 nodeID://b696867 nodeID://b699743 nodeID://b699766 nodeID://b699790 nodeID://b699840 nodeID://b700258 nodeID://b700276 nodeID://b700289 nodeID://b700718 nodeID://b700785 nodeID://b703058 nodeID://b705192 nodeID://b705266 nodeID://b705399 nodeID://b705415 nodeID://b712075 nodeID://b726382

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software