About: Bladder Cancer Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Bladder Cancer Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Bladder Cancer Pathway
rdfs:subClassOf	Cancer Pathway
Semantic_Type	Functional Concept
Preferred_Name	Bladder Cancer Pathway
UMLS_CUI	C2984270
KEGG_ID	hsa05219
ALT_DEFINITION	Bladder cancers arise and progress along two distinctive pathways. The first of these is often preceded by simple and papillary hyperplasia and exhibits a tumour morphology that is low-grade, superficial and papillary. Papillary carcinoma has a tendency to recur locally, but rarely invades and metastasizes. These tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. The second tumour pathway is characterized by high-grade muscle-invasive tumours, which either originate from flat carcinoma in situ (CIS)/severe dysplasia or arise de novo. Over half of these tumours show defects in the tumour suppressors p53 and/or the retinoblastoma protein (RB) genes and pathways, and over 50% of these tumours progress to local and distant metastases. Some of the cell cycle-related molecules show evidence of epigenetic modulation through aberrant promoter hypermethylation in invasive bladder cancer. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF).KEGG
FULL_SYN	Bladder Cancer PathwayPTNCI Bladder cancerPTKEGG
code	C91458
is someValuesFrom of	nodeID://b641476 nodeID://b643007 nodeID://b647976 nodeID://b649106 nodeID://b664913 nodeID://b666085 nodeID://b668066 nodeID://b668094 nodeID://b668109 nodeID://b668123 nodeID://b668296 nodeID://b668553 nodeID://b669206 nodeID://b669231 nodeID://b670457 nodeID://b688290 nodeID://b688557 nodeID://b688643 nodeID://b689052 nodeID://b689147 nodeID://b690954 nodeID://b690964 nodeID://b690992 nodeID://b691386 nodeID://b692043 nodeID://b692059 nodeID://b692082 nodeID://b693242 nodeID://b703387 nodeID://b706606 nodeID://b706707 nodeID://b707250 nodeID://b709320 nodeID://b720313 nodeID://b720330 nodeID://b725657

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 89 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software