About: Neurotrophin Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Neurotrophin Signaling Pathway
rdfs:subClassOf	Cell Differentiation or Development Pathway
Semantic_Type	Functional Concept
Preferred_Name	Neurotrophin Signaling Pathway
UMLS_CUI	C2984256
KEGG_ID	hsa04722
ALT_DEFINITION	Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and negative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.KEGG
FULL_SYN	Neurotrophin Signaling PathwayPTNCI Neurotrophin signaling pathwayPTKEGG
code	C91443
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