About: Biosynthesis of Glycine and Serine Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Biosynthesis of Glycine and Serine Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Biosynthesis of Glycine and Serine Pathway
UMLS_CUI
  • C2984161
BioCarta_ID
  • GlycinePathway
ALT_DEFINITION
  • Intermediates in energy production pathways such as glycolysis and the Kreb's cycle are commonly the starting point for the biosynthesis of amino acids. The glycolytic intermediate 3-phosphoglycerate is the starting point for the biosynthesis of serine and glycine. First, 3-phosphoglycerate is oxidized and then transaminated to produce 3-phosphoserine. Phosphoserine hydrolase hydrolyzes the phosphate in 3-phosphoserine to produce serine. The side chain carbon of serine is removed to create glycine, which has only hydrogen as its side chain. The removal of the serine side chain is accomplished by transferring the carbon to tetrahydrofolate, a carrier of one-carbon groups. Genetic deficiency of the first enzyme in the pathway, 3-phosphoglycerate dehydrogenase, leads to impaired myelination of neurons and impaired development of the central nervous system.BIOCARTA
FULL_SYN
  • Biosynthesis of Glycine and Serine PathwayPTNCI
  • Biosynthesis of Glycine and SerinePTBIOCARTA
code
  • C91320
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