About: Recombinant Tumor Necrosis Factor-Alpha

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Tumor Necrosis Factor-Alpha
equivalentClass	nodeID://b640578
Has_Target	Tumor Necrosis Factor Receptor Superfamily, Member 1A
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Recombinant Tumor Necrosis Factor-Alpha
NSC_Code	697068
UMLS_CUI	C1522669
CAS_Registry	308079-78-9
FDA_UNII_Code	X2C8Z061MB
Contributing_Source	FDA
ALT_DEFINITION	Serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share two receptors.MSH2002_06_01
PDQ_Open_Trial_Search_ID	43225
PDQ_Closed_Trial_Search_ID	43225
Legacy_Concept_Name	Therapeutic_Tumor_Necrosis_Factor-Alpha
FULL_SYN	TUMOR NECROSIS FACTOR-.ALPHA. HUMAN (SOLUBLE FORM)PTFDAX2C8Z061MB Tumor Necrosis Factor (TNF-alpha)SYNCI TNFAABNCI Recombinant Tumor Necrosis Factor-AlphaPTNCI TNF-AlphaSYNCI CachectinSYNCI
DEFINITION	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. Tumor necrosis factor-alpha binds to and activates "death receptors" on the cell surface, resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This agent also disrupts tumor vascularization. (NCI04)NCI
code	C913
is rdfs:subClassOf of	Tumor Necrosis Factor (CET) Tumor Necrosis Factor (Knoll) Tumor Necrosis Factor (GEN)
is someValuesFrom of	nodeID://b660564 nodeID://b663496 nodeID://b663504 nodeID://b665996 nodeID://b671234 nodeID://b683142 nodeID://b683233 nodeID://b683240 nodeID://b683251 nodeID://b683257 nodeID://b683783 nodeID://b683854 nodeID://b692431 nodeID://b711619

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