About: Amantadine Sulfate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amantadine Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Amantadine Sulfate
UMLS_CUI
  • C0002404
CAS_Registry
  • 31377-23-8
FDA_UNII_Code
  • 9921T5P019
Contributing_Source
  • FDA
Chemical_Formula
  • 2C10H17N.H2O4S
FULL_SYN
  • Amantadine SulfatePTNCI
  • AMANTADINE SULFATEPTFDA9921T5P019
DEFINITION
  • The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.NCI
code
  • C90781
is Has_Salt_Form of
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