About: STAT3 Inhibitor OPB-31121     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • STAT3 Inhibitor OPB-31121
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • STAT3 Inhibitor OPB-31121
NCI_META_CUI
  • CL376190
PDQ_Open_Trial_Search_ID
  • 570187
PDQ_Closed_Trial_Search_ID
  • 570187
FULL_SYN
  • STAT3 Inhibitor OPB-31121PTNCI
  • OPB-31121CNNCI
DEFINITION
  • An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. OPB-31121 inhibits the phosphorylation of STAT3, which prevents binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters and may result in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers, contributing to the loss of cell growth control and neoplastic transformation.NCI
code
  • C90588
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