About: c-Met Inhibitor INCB028060     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • c-Met Inhibitor INCB028060
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • c-Met Inhibitor INCB028060
NCI_META_CUI
  • CL416248
PDQ_Open_Trial_Search_ID
  • 666907
PDQ_Closed_Trial_Search_ID
  • 666907
FULL_SYN
  • c-Met Inhibitor INCB028060PTNCI
  • INCB028060CNNCI
DEFINITION
  • An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. c-Met inhibitor INCB028060 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.NCI
code
  • C90564
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