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AttributesValues
rdf:type
rdfs:label
  • Trifluridine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Trifluridine
NSC_Code
  • 75520
UMLS_CUI
  • C0040987
CAS_Registry
  • 70-00-8
FDA_UNII_Code
  • RMW9V5RW38
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39240
PDQ_Closed_Trial_Search_ID
  • 39240
Chemical_Formula
  • C10H11F3N2O5
Legacy_Concept_Name
  • Trifluridine
FULL_SYN
  • TRIFLURIDINEPTFDARMW9V5RW38
  • 2'-Deoxy-5-trifluoromethyluridineSNNCI
  • TrifluridinePTNCI
  • F3TdRABNCI
  • TriflorothymidineSYNCI
DEFINITION
  • A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity. (NCI04)NCI
code
  • C905
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