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AttributesValues
rdf:type
rdfs:label
  • Tobramycin Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Tobramycin Sulfate
NSC_Code
  • 180514
UMLS_CUI
  • C0701392
CAS_Registry
  • 49842-07-1
  • 79645-27-5
FDA_UNII_Code
  • HJT0RXD7JK
Contributing_Source
  • FDA
ALT_DEFINITION
  • An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the Pseudomonas species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39727
PDQ_Closed_Trial_Search_ID
  • 39727
Chemical_Formula
  • 2C18H37N5O9.5H2O4S
Legacy_Concept_Name
  • Tobramycin
FULL_SYN
  • TobrexBRNCI
  • Tobramycin SulfatePTNCI
  • TOBRAMYCIN SULFATEPTFDAHJT0RXD7JK
DEFINITION
  • The sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis. In addition, this agent induces misreading of the mRNA template, which results in 1) detachment of the ribosomal complex and inhibition of protein elongation or 2) incorporation of the incorrect amino acids into the growing polypeptide chain and the production of abnormal or nonfunctional proteins. Altogether, cell permeability is altered and cell death ensues.NCI
code
  • C893
is someValuesFrom of
is Has_Salt_Form of
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