About: Tetraphenyl Chlorin Disulfonate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tetraphenyl Chlorin Disulfonate
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tetraphenyl Chlorin Disulfonate
NCI_META_CUI
  • CL413542
PDQ_Open_Trial_Search_ID
  • 658036
PDQ_Closed_Trial_Search_ID
  • 658036
FULL_SYN
  • TPCS2aABNCI
  • AmphinexFBNCI
  • Tetraphenyl Chlorin DisulfonatePTNCI
  • Disulfonated TetraphenylchlorinSYNCI
DEFINITION
  • A meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl chlorin disulfonate incorporates into the cell's endosome and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate in endosomal and lysosomal compartments; upon local activation by light, tetraphenyl chlorin disulfonate produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic agents are released into the tumor cell cytosol. This photochemical internalization (PCI) method can enhance the efficacy and selectivity of cytotoxic agents.NCI
code
  • C88344
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