About: Docetaxel Formulation CKD-810     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Docetaxel Formulation CKD-810
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Docetaxel Formulation CKD-810
NCI_META_CUI
  • CL413582
PDQ_Open_Trial_Search_ID
  • 661020
PDQ_Closed_Trial_Search_ID
  • 661020
FULL_SYN
  • Docetaxel Formulation CKD-810PTNCI
  • CKD-810CNNCI
DEFINITION
  • An injectable formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response.NCI
code
  • C88322
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