About: Iodine I-123 ADAM

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Attributes	Values
rdf:type	Class
rdfs:label	Iodine I-123 ADAM
rdfs:subClassOf	Radioconjugate
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Iodine I-123 ADAM
NCI_META_CUI	CL413579
CAS_Registry	305352-16-3
FDA_UNII_Code	20LJC2LC2J
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	660864
PDQ_Closed_Trial_Search_ID	660864
Chemical_Formula	C15H17IN2S
FULL_SYN	Iodine I-123 ADAMPTNCI ADAM I-123PTFDA20LJC2LC2J ADAM I-123SYNCI Iodine-123-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamineSNNCI
DEFINITION	A radiopharmaceutical containing the serotonin transporter (SERT) ligand ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine] labeled with the radioisotope iodine I 123, with SERT-binding and radioisotope activities. Upon administration, iodine I 123 ADAM selectively binds to SERT-expressing cells; subsequently, SERT-expressing tissues may be visualized using single photon emission computed tomography (SPECT). SERT is a monamine transporter protein found in the membranes of neurons and platelets; in neurons it transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons, terminating serotonin's function.NCI
code	C88319

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