About: Tasisulam Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tasisulam Sodium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tasisulam Sodium
PubMedID_Primary_Reference
  • 18949427
NCI_META_CUI
  • CL413622
CAS_Registry
  • 519055-63-1
FDA_UNII_Code
  • O3955SHR9J
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 506118
PDQ_Closed_Trial_Search_ID
  • 506118
Chemical_Formula
  • C11H5BrCl2NO3S2.Na
FULL_SYN
  • LY-573636.NaCNNCI
  • LY573636-SodiumCNNCI
  • TASISULAM SODIUMPTFDAO3955SHR9J
  • Tasisulam SodiumPTNCI
  • Benzamide, N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichloro-, Sodium SaltSNNCI
DEFINITION
  • The sodium salt of an acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity.NCI
code
  • C88304
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