About: Iodine I-124 FIAU

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Attributes	Values
rdf:type	Class
rdfs:label	Iodine I-124 FIAU
rdfs:subClassOf	Radioconjugate
Semantic_Type	Pharmacologic Substance
Preferred_Name	Iodine I-124 FIAU
NCI_META_CUI	CL413534
PDQ_Open_Trial_Search_ID	656874
PDQ_Closed_Trial_Search_ID	656874
FULL_SYN	124I-2-Fluoro-2-deoxy-5-[124I]iodo-1beta-d-arabinofuranosyluracilSNNCI Iodine I-124 FIAUPTNCI 124I-FIAUABNCI
DEFINITION	A radioconjugate containing the nucleoside analog 2'-fluoro-2'-deoxy-1beta-D-arabinofuranosyl-5-iodouracil (FIAU) labeled with the radioisotope iodine I 124 with positron-emitting activity. Chemotherapeutic agents such as bortezomib may induce viral thymidine kinase expression in EBV- and Kaposi's sarcoma herpesvirus (KSHV)-associated tumors. Subsequent to chemotherapy induction of viral TK in these tumors, administered iodine I 124 FIAU is phosphorylated by expressed viral TK, becoming selectively trapped within TK-expressing tumor cells; these cells can then be visualized with positron emission tomography (PET). Viral TK is either not expressed or is expressed at very low levels in EBV- and Kaposi's sarcoma herpesvirus (KSHV)-associated tumors and may be activated by certain chemotherapeutic agents.NCI
code	C88284

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