About: Technetium Tc-99m Demobesin-4     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Technetium Tc-99m Demobesin-4
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Technetium Tc-99m Demobesin-4
NCI_META_CUI
  • CL412465
ALT_DEFINITION
  • A substance being studied as a way to find certain types of cancer. It contains a radioactive substance called technetium linked to another substance called demobesin. Demobesin binds to the receptor for bombesin (a substance that is found at higher-than-normal levels on some types of cancer cells). Technetium Tc 99m demobsin-4 collects in cancer cells and a machine is used to find where the cancer cells are in the body. It is a type of radiopharmaceutical and a type of radioimaging agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 656155
PDQ_Closed_Trial_Search_ID
  • 656155
FULL_SYN
  • 99mTc Demobesin-4SYNCI
  • Technetium Tc-99m Demobesin-4PTNCI
  • technetium Tc 99m demobesin-4PTNCI-GLOSSCDR0000661207
DEFINITION
  • A radioconjugate composed of the synthetic bombesin (BB) analog demobesin-4 bound to the radioisotope technetium Tc 99m with receptor ligand and gamma-emitting radioisotope activities. Upon intravenous administration, demobesin-4 selectively binds to the gastrin-releasing peptide receptor (GRPR) expressed on the surfaces of various tumor cell types; upon internalization, tumor cells expressing GRPRs bound to technetium Tc 99m can then be visualized using scintigraphy. GRPR, a bombesin receptor subtype, is frequently overexpressed on the surface of tumor cells such as prostate and breast cancer cells. Demobesin-4 was developed for technetium Tc 99m imaging of GRPR-expressing tumor cells.NCI
code
  • C88276
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