About: Thioguanine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Thioguanine
equivalentClass	nodeID://b640586
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Thioguanine
NSC_Code	752
UMLS_CUI	C0039902
CAS_Registry	154-42-7 5580-03-0
Accepted_Therapeutic_Use_For	Acute nonlymphocytic leukemia
In_Clinical_Trial_For	Acute lymphoblastic leukemia; Acute myeloid leukemia; Brain tumors; Lymphoblastic non-Hodgkins lymphoma; Myelodysplastic syndrome
FDA_UNII_Code	FTK8U1GZNX
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called antimetabolites.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43669
PDQ_Closed_Trial_Search_ID	43669
Chemical_Formula	C5H5N5S.H2O
Legacy_Concept_Name	Thioguanine
FULL_SYN	ThioguanineSYDTPNSC0000752 2-Amino 6MPSNNCI Wellcome U3BSYDTPNSC0000752 ThioguaninePTNCI Wellcome U3BCNNCI 2-Aminopurin-6-thiolSYDTPNSC0000752 2-Amino-6-mercaptopurineSNNCI 6-Mercapto-2-aminopurineSNNCI 6 ThioguanineSNNCI 6-ThioguanineSNNCI thioguaninePTNCI-GLOSSCDR0000046765 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)SNNCI 2-Amino-6-purinethiolSYDTPNSC0000752 2-Aminopurine-6-thiolSYDTPNSC0000752 BW 5071SYDTPNSC0000752 LanvisSYDTPNSC0000752 2-Aminopurine-6(1H)-thioneSNNCI X 27CNNCI 6-TGABNCI TabloidSYDTPNSC0000752 2-Amino-1,7-dihydro-6H-purine-6-thioneSNNCI 6 MercaptoguanineSNNCI LanvisFBNCI BW 5071CNNCI WR-1141CNNCI 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)SYDTPNSC0000752 TabloidBRNCI TioguaninSYDTPNSC0000752 2-Amino-6-mercaptopurineSYDTPNSC0000752 6-Amino-2-mercaptopurineSYDTPNSC0052758 2-Mercapto-6-aminopurineSYDTPNSC0052758 6-Mercapto-2-aminopurineSYDTPNSC0000752 6-MercaptoguanineSYDTPNSC0000752 2-Aminopurin-6-thiolSNNCI TioguanineSYDTPNSC0000752 THIOGUANINEPTFDAFTK8U1GZNX 2-Amino 6MPSYDTPNSC0000752 2-Amino-1,7-dihydro-6H-purine-6-thionePTDCP06268 TioguaninFBNCI 2-Amino-6-purinethiolSNNCI 2-Aminopurine-6-thiolSNNCI 2-Aminopurine-6(1H)-thioneSYDTPNSC0000752 X 27SYDTPNSC0000752 TioguanineBRNCI
DEFINITION	A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)NCI
code	C876
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