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AttributesValues
rdf:type
rdfs:label
  • Sodium Selenite
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sodium Selenite
UMLS_CUI
  • C0142923
CAS_Registry
  • 10102-18-8
FDA_UNII_Code
  • HIW548RQ3W
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 681583
PDQ_Closed_Trial_Search_ID
  • 681583
Chemical_Formula
  • 2Na.O3Se
CHEBI_ID
  • CHEBI:48843
FULL_SYN
  • Selenious Acid, Sodium Salt (1:2)SYNCI
  • SODIUM SELENITEPTFDAHIW548RQ3W
  • Sodium SelenitePTNCI
  • Disodium Selenium TrioxideSYNCI
  • Selenious Acid Disodium SaltSYNCI
DEFINITION
  • An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.NCI
code
  • C87346
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