About: Tetradecanoylphorbol Acetate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tetradecanoylphorbol Acetate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
Preferred_Name
  • Tetradecanoylphorbol Acetate
NSC_Code
  • 262244
UMLS_CUI
  • C0039654
CAS_Registry
  • 16561-29-8
In_Clinical_Trial_For
  • Hematologic cancer; bone marrow disorder
FDA_UNII_Code
  • NI40JAQ945
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of leukemias and lymphomas. It is also being studied in the treatment of other types of cancer. Tetradecanoylphorbol acetate affects many cell actions and may cause tumor cells to die. It is a type of phorbol ester.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43661
PDQ_Closed_Trial_Search_ID
  • 43661
Chemical_Formula
  • C36H56O8
Legacy_Concept_Name
  • Tetradecanoylphorbol_Acetate
CHEBI_ID
  • CHEBI:37537
FULL_SYN
  • PMAABNCI
  • TPAPTNCI-GLOSSCDR0000044864
  • Phorbol Myristate AcetateSYNCI
  • 12-O-tetradecanoylphorbol-13-acetateSNNCI
  • PHORBOL 12-MYRISTATE 13-ACETATE DIESTERPTFDANI40JAQ945
  • Tetradecanoylphorbol AcetatePTNCI
  • TPA (Phorbol Ester)SYNCI
  • tetradecanoylphorbol acetatePTNCI-GLOSSCDR0000663334
  • 12-O-tetradecanoylphorbol-13-acetatePTNCI-GLOSSCDR0000046763
  • LonomycinSYNCI
DEFINITION
  • A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)NCI
code
  • C866
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