About: Multikinase Inhibitor ARRY614     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Multikinase Inhibitor ARRY614
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Multikinase Inhibitor ARRY614
NCI_META_CUI
  • CL412366
PDQ_Open_Trial_Search_ID
  • 647828
PDQ_Closed_Trial_Search_ID
  • 647828
FULL_SYN
  • Multikinase Inhibitor ARRY614PTNCI
  • ARRY-614CNNCI
DEFINITION
  • An orally bioavailable small-molecule inhibitor of p38 and Tie2 kinases with potential antineoplastic, anti-inflammatory and antiangiogenic activities. p38/Tie2 kinase inhibitor Arry-614 binds to and inhibits the activities of p38 and Tie2 kinases, which may inhibit the production of proinflammatory cytokines and may decrease tumor angiogenesis and tumor cell growth and survival. p38 is a MAP kinase that is often upregulated in cancer cells, playing a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6. Tie2 is an endothelial cell specific receptor that is activated by angiopoietins, growth factors required for angiogenesis. This agent has also been reported to inhibit other kinases including vascular endothelial growth factor receptor (VEGFR2) and Src tyrosine kinases.NCI
code
  • C85481
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