About: Ferumoxides Injectable Solution

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Attributes	Values
rdf:type	Class
rdfs:label	Ferumoxides Injectable Solution
rdfs:subClassOf	Contrast Agent
Semantic_Type	Indicator, Reagent, or Diagnostic Aid
Preferred_Name	Ferumoxides Injectable Solution
UMLS_CUI	C1250871
PDQ_Open_Trial_Search_ID	647806
PDQ_Closed_Trial_Search_ID	647806
FULL_SYN	FeridexBRNCI Ferumoxides Injectable SolutionPTNCI
DEFINITION	An injectable, aqueous colloid solution containing a non-stoichiometric magnetite core of superparamagnetic iron oxide (SPIO) coated with dextran administered as a magnetic resonance imaging (MRI) contrast media. Upon intravenous administration, ferumoxides accumulates in phagocytic reticuloendothelial system (RES) cells of the liver (Kupffer cells). When exposed to a strong external magnetic field, ferumoxides exhibits enhanced T2 relaxation, resulting in signal loss in normal tissues (image darkening) on mid T1/T2 or strongly T2-weighted images. Tissues with decreased RES function such as metastases, primary liver cancer, cysts and various benign tumors, adenomas, and hyperplasia, retain their native signal intensity, consequently the contrast between normal tissue (with image darkening) and abnormal tissue is increased.NCI
code	C85477

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