About: pan-PI3K/mTOR Inhibitor SF1126     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • pan-PI3K/mTOR Inhibitor SF1126
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • pan-PI3K/mTOR Inhibitor SF1126
UMLS_CUI
  • C2351370
PDQ_Open_Trial_Search_ID
  • 644818
PDQ_Closed_Trial_Search_ID
  • 644818
FULL_SYN
  • SF1126CNNCI
  • pan-PI3K/mTOR Inhibitor SF1126PTNCI
DEFINITION
  • A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival.NCI
code
  • C85469
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