About: Iodine I 131 Phospholipid Ether Analogue CLR1404     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Iodine I 131 Phospholipid Ether Analogue CLR1404
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Iodine I 131 Phospholipid Ether Analogue CLR1404
NCI_META_CUI
  • CL412381
PDQ_Open_Trial_Search_ID
  • 649140
PDQ_Closed_Trial_Search_ID
  • 649140
FULL_SYN
  • I-131-CLR1404ABNCI
  • I-131 PLE Analogue CLR1404SYNCI
  • Iodine I 131 Phospholipid Ether Analogue CLR1404PTNCI
DEFINITION
  • A small-molecule radiopharmaceutical consisting of the beta-emitting radioisotope iodine I 131 attached to a phospholipid ether (PLE) analogue, comprised of a linear 18 carbon backbone, with potential antineoplastic activity. Iodine I 131 phospholipid ether analogue CLR1404 selectively accumulates in tumor cells, thereby delivering a cytotoxic dose of radiation to cancer cells. Compared to normal cells, tumor cells are unable to metabolize and eliminate PLEs possibly due to deficiency of the enzyme phospholipase-D. In addition, the radioiodine moiety of this agent is resistant to de-iodination.NCI
code
  • C84879
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