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AttributesValues
rdf:type
rdfs:label
  • Galeterone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Galeterone
UMLS_CUI
  • C1569220
CAS_Registry
  • 851983-85-2
FDA_UNII_Code
  • WA33E149SW
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 653977
PDQ_Closed_Trial_Search_ID
  • 653977
Chemical_Formula
  • C26H32N2O
FULL_SYN
  • Specific Androgen Receptor Modulator/CYP17 Lyase Inhibitor TOK-001SYNCI
  • VN/124CNNCI
  • TOK-001CNNCI
  • GALETERONEPTFDAWA33E149SW
  • VN/124-1CNNCI
  • Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3beta)-SNNCI
  • GaleteronePTNCI
DEFINITION
  • An orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.NCI
code
  • C84866
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