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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Menadione Topical Lotion
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Menadione Topical Lotion
NCI_META_CUI
  • CL412424
PDQ_Open_Trial_Search_ID
  • 652615
PDQ_Closed_Trial_Search_ID
  • 652615
FULL_SYN
  • Menadione Topical LotionPTNCI
DEFINITION
  • A topical lotion containing the small organic molecule protein tyrosine phosphatase (PTP) inhibitor menadione (vitamin K3) with potential EGFR- and ErbB2/HER2-activating activities. Upon topical administration, menadione binds to and inhibits the activity of PTPs that dephosphorylate and inactivate EGFR and ErbB2 in human keratinocytes; local reversal of EGFR and ErbB2 inhibition associated with the systemic administration of EGFR inhibitors may help alleviate EGFR inhibitor-mediated skin toxicity. EGFR (epidermal growth factor receptor) and ErbB2/HER2 (erythroblastic leukemia viral oncogene homolog 2/ human epidermal growth factor receptor 2) are cell surface receptors that are upregulated in a number of cancer cells types and play important roles in the growth and maintenance of normal epithelial tissues.NCI
code
  • C84863
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