About: 16,16-Dimethyl Prostaglandin E2     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 16,16-Dimethyl Prostaglandin E2
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • 16,16-Dimethyl Prostaglandin E2
NCI_META_CUI
  • CL412404
PDQ_Open_Trial_Search_ID
  • 651165
PDQ_Closed_Trial_Search_ID
  • 651165
FULL_SYN
  • dmPGE2ABNCI
  • 16,16-Dimethyl Prostaglandin E2PTNCI
DEFINITION
  • A stable derivative of prostaglandin E2 (PGE2) with potential hematopoietic activity. Administration of 16,16 dimethyl-prostaglandin E2 (dmPGE2) appears to lead to increased formation of hematopoietic stem and progenitor cells. Even though the exact mechanism of action has yet to be fully elucidated, this agent may stimulate hematopoiesis by activating the Wnt signaling pathway, which increases cellular levels of beta-catenin, a subunit of the cadherin protein complex.NCI
code
  • C84850
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