About: Tafamidis Meglumine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tafamidis Meglumine
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tafamidis Meglumine
UMLS_CUI
  • C2745276
CAS_Registry
  • 951395-08-7
FDA_UNII_Code
  • ZU7CF08A1A
Contributing_Source
  • FDA
Chemical_Formula
  • C14H7Cl2NO3.C7H17NO5
FULL_SYN
  • D-Glucitol, 1-Deoxy-1-(Methylamino)-, 2-(3,5-Dichlorophenyl)-6-Benzoxazolecarboxylate (1:1)SNNCI
  • FX-1006ACNNCI
  • Tafamidis MegluminePTNCI
  • TAFAMIDIS MEGLUMINEPTFDAZU7CF08A1A
  • D-Gluco-2,3,4,5,6-Pentahydroxy-N-Methylhexan-1-Aminium 2-(3,5-Dichlorophenyl)Benzoxazole-6-CarboxylateSNNCI
DEFINITION
  • A soft gelatin capsule formulation containing the meglumine salt form of tafamidis, a small molecule and pharmacological chaperone with potential disease-modifying activity. Tafamidis binds to and stabilizes wild-type and variant (V122I) transthyretin (TTR), thereby preventing tetramer dissociation into monomers; this prevents misfolding of the TTR protein and inhibits the formation of TTR amyloid fibrils and the subsequent deposition of these insoluble protein clusters in peripheral nerve tissues and organs. TTR is a 127 amino acid transport protein for thyroxine and retinol and is secreted by the liver.NCI
code
  • C84194
is Has_Salt_Form of
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