About: Davalintide Acetate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Davalintide Acetate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Davalintide Acetate
UMLS_CUI
  • C2827126
CAS_Registry
  • 879197-42-9
FDA_UNII_Code
  • 4QM48103XT
Contributing_Source
  • FDA
Chemical_Formula
  • C152H248N50O49S2.C2H4O2
FULL_SYN
  • L-Lysyl-Des-2-L-Serine-(4-L-Threonine(Lt), 5-L-Alanine(Sa),11-L-Arginine(Kr),18-L-Arginine(Kr),30-L-Asparagine(Gn),32-L-Tyrosine(Py))Calcitonin-1 Oncorhynchus Keta (Chum Salmon), Calcitonin-1 Precursor-(83-114)-Peptidamide Acetate SaltSNNCI
  • L-Tyrosinamide, L-Lysyl-L-Cysteinyl-L-Asparaginyl-L-Threonyl-L-Alanyl-L-Threonyl-L-Cysteinyl-L-Valyl-L-Leucylglycyl-L-Arginyl-L-Leucyl-L-Seryl-L-Glutaminyl-L-.Alpha.-Glutamyl-L-Leucyl-L-Histidyl-L-Arginyl-L-Leucyl-L-Glutaminyl-L-Threonyl-L-Tyrosyl-L-Proly AcetateSYNCI
  • Davalintide AcetatePTNCI
  • DAVALINTIDE ACETATEPTFDA4QM48103XT
DEFINITION
  • The acetate salt form of davalintde, a second-generation, 32-amino acid peptide analogue of human amylin with antihyperglycemic activity. By mimicking amylin, davalintide, which has a half-life similar to amylin, slows gastric emptying, inhibits digestive secretions (gastric acid, pancreatic enzymes, and bile), reduces glucagon secretion, and increases satiety. These actions results in a decrease in blood glucose levels. Furthermore, davalintide exhibits high affinity binding to amylin, calcitonin and calcitonin-related peptide receptors. Compared to amylin, davalintide shows a prolonged duration of action due to its slowed receptor dissociation.NCI
code
  • C83651
is Has_Salt_Form of
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