About: Sheddase Inhibitor INCB007839     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sheddase Inhibitor INCB007839
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sheddase Inhibitor INCB007839
NCI_META_CUI
  • CL388480
PDQ_Open_Trial_Search_ID
  • 633945
PDQ_Closed_Trial_Search_ID
  • 633945
Legacy_Concept_Name
  • Sheddase_Inhibitor_INCB007839
FULL_SYN
  • Sheddase Inhibitor INCB007839PTNCI
  • INCB007839CNNCI
DEFINITION
  • An orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Sheddase inhibitor INCB007839 represses the metalloproteinase ""sheddase"" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or ""shedding"" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM). ADAM10 processes particular epithelial growth factor receptor (EGFR) ligands and appears to regulate Notch signaling through the cleavage of Notch and its related ligand delta-like ligand-1 (Dll-1). ADAM17 (also known as Tumor necrosis factor-Converting Enzyme or TACE) is involved in processing tumor necrosis factor (TNF) from its membrane bound precursor to its soluble circulating form and in processing ligands for the epidermal growth factor receptor (EGFR) family.NCI
code
  • C82692
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