About: Amifampridine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Amifampridine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amifampridine
NSC_Code
  • 521760
UMLS_CUI
  • C0046948
CAS_Registry
  • 54-96-6
FDA_UNII_Code
  • RU4S6E2G0J
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 633588
PDQ_Closed_Trial_Search_ID
  • 633588
Chemical_Formula
  • C5H7N3
Legacy_Concept_Name
  • _3_4-Diaminopyridine
FULL_SYN
  • Pyridine, 3,4-Diamino-SNNCI
  • AmifampridinePTNCI
  • 3,4-DiaminopyridineSNNCI
  • AMIFAMPRIDINEPTFDARU4S6E2G0J
  • SC10CNNCI
  • 3,4-DAPABNCI
  • 3,4-PyridinediamineSYNCI
  • 4,5-DiaminopyridineSYNCI
DEFINITION
  • An organic compound derived from pyridine with potassium channel inhibition activity. Amifampridine inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.NCI
code
  • C82687
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