About: Irinotecan-Eluting Beads     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Irinotecan-Eluting Beads
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Irinotecan-Eluting Beads
NCI_META_CUI
  • CL388467
PDQ_Open_Trial_Search_ID
  • 632992
PDQ_Closed_Trial_Search_ID
  • 632992
Legacy_Concept_Name
  • Irinotecan-Eluting_Beads
FULL_SYN
  • Irinotecan-Eluting BeadsPTNCI
DEFINITION
  • Microporous hydrospheres of polyvinylalcohol (PVA) impregnated with irinotecan with potential antineoplastic activity. In transarterial chemoembolization (TACE), irinotecan-eluting beads are administered into blood vessels that feed the tumor, occluding tumor blood vessels and inducing ischemic tumor necrosis while simultaneously delivering high-dose chemotherapy locally. Irinotecan, a semisynthetic derivative of camptothecin, inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.NCI
code
  • C82682
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