About: Pegylated Recombinant Human Hyaluronidase PH20     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pegylated Recombinant Human Hyaluronidase PH20
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pegylated Recombinant Human Hyaluronidase PH20
NCI_META_CUI
  • CL388491
PDQ_Open_Trial_Search_ID
  • 636196
PDQ_Closed_Trial_Search_ID
  • 636196
Legacy_Concept_Name
  • Pegylated_Recombinant_Human_Hyaluronidase_PH20
FULL_SYN
  • Pegylated Recombinant Human Hyaluronidase PH20PTNCI
  • PH20CNNCI
  • Pegylated rHuPH20SYNCI
  • PEGPH20ABNCI
  • Pegylated Recombinant Human PH20SYNCI
DEFINITION
  • A pegylated formulation of a recombinant form of human hyaluronidase with potential antitumor activity. Upon intravenous administration, pegylated recombinant human PH20 degrades hyaluronic acid (HA) coating tumor cells, which may result in the inhibition of tumor cell growth. In addition, the degradation of HA may result in a lowering of the interstitial fluid pressure (IFP), allowing better penetration of chemotherapeutic agents into the tumor bed. HA is a glycosaminoglycan found in the extracellular matrix (ECM) that is frequently overproduced by various tumor cell types. The presence of HA in tumors correlates with increased tumor cell growth, metastatic potential, tumor progression, increased resistance to chemotherapeutic agents, and an elevation in tumor IFP.NCI
code
  • C82659
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